The results of sex-change operations

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"The results disturbed him. Although most of the patients 'were reasonably satisfied with the change, they hadn't any improvement in any of their psychosocial issues that were the whole reason for doing it in the first place.'

Worse, some of the patients became 'suicidal and depressed and regretful.' There was not enough good evidence to determine before the fact which candidates for surgery would fall into either group."

- a profile on Dr. Paul McHugh, who shut down Johns Hopkins' pioneering sex-change surgery center in 1979 [1]